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Revista Brasileira de Ginecologia e Obstetrícia. 2009;31(5):230-234
DOI 10.1590/S0100-72032009000500005
PURPOSE: to evaluate the patient's age as an outcome predictor in an in vitro fertilization (IVF) program. METHODS: transversal study, which has included 302 women with ages varying from 24 to 46 years old, submitted to IVF, from May 2005 to July 2007. The patients were divided in three groups, according to their age: G<35 (n=161), G 36-39 (n=89) e G>40 (n=52). The number of collected oocytes, the fertilization rates, the number of transferred embryos, the embryonary quality and the pregnancy rate were evaluated. Statistical analysis was realized through Kruskal-Wallis variance analysis and χ2 test. RESULTS: in the G<35 group, an average of 8.8 oocytes by patient was obtained; in the G 36-49 group, 7.4; and in the G>40 group, 1.6. The number of oocytes obtained in G>40 group was significantly lower than in the other two groups (p<0.001).The fertilization rate was similar in the three groups, 61.4, 65.8 e 64.6% (p=0.2288), respectively. The percentage of good quality embryos was not statistically different among the three groups either, with rates of 57.4, 63.2 and 56.0% (p=0.2254), respectively. The average number of transferred embryos in each group was 3.1 (G<35), 2.8 (G 36-39) and 1.5 (G>40), respectively, with statistically significant decrease in the G>40 group (p<0.001). Concerning pregnancy rates, the G>40 group has presented a rate of 9.6%, a result which is significantly lower (p=0.0330) than the one presented by the G<35 and G 36-39 groups (26.1 e 27.0%, respectively), with no significant difference between themselves. CONCLUSIONS: though the embryonary quality is not different among women from different age groups, the number of collected oocytes, the number of transferred embryos and the pregnancy rate indicate that the women's age is an important predictive factor of success for the techniques of assisted reproduction and should be taken into consideration when this kind of treatment is proposed to women over 40.
Summary
Revista Brasileira de Ginecologia e Obstetrícia. 2009;31(5):230-234
DOI 10.1590/S0100-72032009000500005
PURPOSE: to evaluate the patient's age as an outcome predictor in an in vitro fertilization (IVF) program. METHODS: transversal study, which has included 302 women with ages varying from 24 to 46 years old, submitted to IVF, from May 2005 to July 2007. The patients were divided in three groups, according to their age: G<35 (n=161), G 36-39 (n=89) e G>40 (n=52). The number of collected oocytes, the fertilization rates, the number of transferred embryos, the embryonary quality and the pregnancy rate were evaluated. Statistical analysis was realized through Kruskal-Wallis variance analysis and χ2 test. RESULTS: in the G<35 group, an average of 8.8 oocytes by patient was obtained; in the G 36-49 group, 7.4; and in the G>40 group, 1.6. The number of oocytes obtained in G>40 group was significantly lower than in the other two groups (p<0.001).The fertilization rate was similar in the three groups, 61.4, 65.8 e 64.6% (p=0.2288), respectively. The percentage of good quality embryos was not statistically different among the three groups either, with rates of 57.4, 63.2 and 56.0% (p=0.2254), respectively. The average number of transferred embryos in each group was 3.1 (G<35), 2.8 (G 36-39) and 1.5 (G>40), respectively, with statistically significant decrease in the G>40 group (p<0.001). Concerning pregnancy rates, the G>40 group has presented a rate of 9.6%, a result which is significantly lower (p=0.0330) than the one presented by the G<35 and G 36-39 groups (26.1 e 27.0%, respectively), with no significant difference between themselves. CONCLUSIONS: though the embryonary quality is not different among women from different age groups, the number of collected oocytes, the number of transferred embryos and the pregnancy rate indicate that the women's age is an important predictive factor of success for the techniques of assisted reproduction and should be taken into consideration when this kind of treatment is proposed to women over 40.
Summary
Revista Brasileira de Ginecologia e Obstetrícia. 2002;24(10):212-216
DOI 10.1590/S0100-72032002001000006
PURPOSE: to compare two methodologies for the calculation of placental volume in normal term pregnancies: one according to the Archimedes principle and the other to the cylinder volume, to estimate the absolute placental densities. Also, to define the methodology which relates to the weight and to the newborn classification. METHOD: fifty placentas from normal term pregnancies were tested by the two methodologies to estimate the placental volume and absolute density: a) Archimedes principle, and b) the cylinder volume with two possible different heights. The absolute placental densities were calculated, respectively, by the quotient between the placenta weight, properly standardized, and the different estimated volumes. RESULTS: most of the pregnant women had more than one gestation, average age of 25.4 years, mean placental volume between 547.8 and 610 cm³ and mean density between 0.94 and 1.14 g/cm³, depending on the used methodology. CONCLUSIONS: the Archimedes principle was the most appropriate methodology to estimate the term placental volume, best correlating with the newborn weight, the placental index and the classification of newborn weight in relation to gestational age.
Summary
Revista Brasileira de Ginecologia e Obstetrícia. 2002;24(10):212-216
DOI 10.1590/S0100-72032002001000006
PURPOSE: to compare two methodologies for the calculation of placental volume in normal term pregnancies: one according to the Archimedes principle and the other to the cylinder volume, to estimate the absolute placental densities. Also, to define the methodology which relates to the weight and to the newborn classification. METHOD: fifty placentas from normal term pregnancies were tested by the two methodologies to estimate the placental volume and absolute density: a) Archimedes principle, and b) the cylinder volume with two possible different heights. The absolute placental densities were calculated, respectively, by the quotient between the placenta weight, properly standardized, and the different estimated volumes. RESULTS: most of the pregnant women had more than one gestation, average age of 25.4 years, mean placental volume between 547.8 and 610 cm³ and mean density between 0.94 and 1.14 g/cm³, depending on the used methodology. CONCLUSIONS: the Archimedes principle was the most appropriate methodology to estimate the term placental volume, best correlating with the newborn weight, the placental index and the classification of newborn weight in relation to gestational age.
