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  • Original Article

    Abnormal vaginal secretion: sensitivity, specificity and concordance between clinical and cytological diagnosis

    Rev Bras Ginecol Obstet. 2015;37(5):222-228

    Summary

    Original Article

    Abnormal vaginal secretion: sensitivity, specificity and concordance between clinical and cytological diagnosis

    Rev Bras Ginecol Obstet. 2015;37(5):222-228

    DOI 10.1590/SO100-720320150005183

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    PURPOSE:

    To estimate the prevalence of bacterial vaginosis (BV), candidiasis and
    trichomoniasis and compare the findings of physical examination of the vaginal
    secretion with the microbiological diagnosis obtained by cytology study of a
    vaginal smear using the Papanicolaou method.

    METHODS:

    A cross-sectional study of 302 women aged 20 to 87 years, interviewed and
    submitted to a gynecology test for the evaluation of vaginal secretion and
    collection of a cytology smear, from June 2012 to May 2013. Sensitivity analyses
    were carried out and specificity, positive predictive value (PPV) and negative
    predictive value (NPV) with their respective 95%CI were determined to assess the
    accuracy of the characteristics of vaginal secretion in relation to the
    microbiological diagnosis of the cytology smear . The kappa index (k) was used to
    assess the degree of agreement between the clinical features of vaginal secretion
    and the microbiological findings obtained by cytology.

    RESULTS

    The prevalence of BV, candidiasis and trichomoniasis was 25.5, 9.3 and 2.0%,
    respectively. The sensitivity, specificity, PPV and NPV of the clinical
    characteristics of vaginal secretion for the cytological diagnosis of BV were 74,
    78.6, 54.3 and 89.9%, respectively. The sensitivity, specificity, PPV and the NPV
    of the clinical characteristics of vaginal secretion for the cytological diagnosis
    of candidiasis were 46.4, 86.2, 25.5 and 94%, respectively. The correlation
    between the clinical evaluation of vaginal secretion and the microbiological
    diagnosis of BV, candidiasis and trichomoniasis, assessed by the kappa index, was
    0.47, 0.23 and 0.28, respectively.

    CONCLUSION

    The most common cause of abnormal vaginal secretion was BV. The clinical
    evaluation of vaginal secretion presented amoderate to weak agreement with the
    microbiological diagnosis, indicating the need for complementary investigation of
    the clinical findings of abnormal vaginal secretion.

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