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You searched for:"José Carlos Souza Trindade"
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Rev Bras Ginecol Obstet. 1999;21(4):209-214
DOI 10.1590/S0100-72031999000400005
Purpose: to develop an experimental model in rats to study the interaction between hypertension and pregnancy. Methods: the present experiment was divided into 5 periods: adaptation (2 weeks), surgical procedures (1 week), hypertension development (6 weeks), mating and blood pressure stabilization (6 weeks), and gestational period (3 weeks). A total of 82 animals in reproductive age, weighing from 180 to 240 g, were used. They were randomly assigned to the 4 different groups (control, handled, nephrectomy and hypertension) and renal hypertension was produced by a controlled constriction of the main left renal artery, according to the technique described by Goldblatt, and contralateral nephrectomy (Goldblatt I - one kidney, one clip hypertension). They were studied at 15 precise moments. Afterwards, periodic blood pressure determinations were made by the tail plethysmographic method. Results: pregnancy caused a fall in blood pressure levels in the rat. Conclusion: the experimental model was adequate for the purposes of the study, since it proved to be efficient in producing hypertension.
Summary
Rev Bras Ginecol Obstet. 1999;21(4):209-214
DOI 10.1590/S0100-72031999000400005
Purpose: to develop an experimental model in rats to study the interaction between hypertension and pregnancy. Methods: the present experiment was divided into 5 periods: adaptation (2 weeks), surgical procedures (1 week), hypertension development (6 weeks), mating and blood pressure stabilization (6 weeks), and gestational period (3 weeks). A total of 82 animals in reproductive age, weighing from 180 to 240 g, were used. They were randomly assigned to the 4 different groups (control, handled, nephrectomy and hypertension) and renal hypertension was produced by a controlled constriction of the main left renal artery, according to the technique described by Goldblatt, and contralateral nephrectomy (Goldblatt I - one kidney, one clip hypertension). They were studied at 15 precise moments. Afterwards, periodic blood pressure determinations were made by the tail plethysmographic method. Results: pregnancy caused a fall in blood pressure levels in the rat. Conclusion: the experimental model was adequate for the purposes of the study, since it proved to be efficient in producing hypertension.
Summary
Rev Bras Ginecol Obstet. 2004;26(4):311-316
DOI 10.1590/S0100-72032004000400008
OBJECTIVE: to assess the concordance of different urodynamic parameters with simplified cystometry, thus improving the cost-benefit relationship for stress urinary incontinence (SUI) diagnosis in woman. METHODS: we evaluated retrospectively the medical records of thirty patients treated, from January 2000 to March 2001. All patients had been submitted to physical and gynecological examinations. A conventional urodynamic study had been made using a Dynograph R-611 recorder. Simplified cystometry had used a saline tube with "Y" connector, connected to a Foley 14 Fr catheter, which allowed measurement of intra-vesical pressure at the same time as physiological saline infusion. The following parameters were analyzed: residual volume, bladder capacity, complacency, involuntary detrusor contractions, and abdominal leak-point pressure. The Pearson test of agreement and the Wilcoxon signed rank test were used to verify the concordance between related samples, with p < 0,05. RESULTS: the average age was 50 years old (28-70). Concordance between studies for stress urinary losses was 67%, and for detrusor involuntary contractions, 90%. The average residual volume was significantly different: by simplified cystometry it was 16.8 ml versus 2 ml by conventional urodynamics (p < 0.01). The average maximum vesical capacity by urodynamic study was 440.5 ml, and by simplified cystometry, 387 ml (p < 0.05). Vesical complacency was on average, significantly larger in simplified cystometry (43.0 ml/cmH2O) than in the urodynamic study (31.5 ml/cmH2O), with p < 0.01. CONCLUSION: preliminary evaluations suggest that the urogynecologic propedeutic associated with cystometry is an option to be considered in the clinical and preoperative assessment of patients with SUI instead of conventional urodynamics, particularly when the latter is not available. Simplified cystometry is an accessible exam that grants comparable results for the detection of involuntary detrusor contractions and for the identification of urinary loss, providing the examiner with trustworthy data on vesical behavior.
Summary
Rev Bras Ginecol Obstet. 2004;26(4):311-316
DOI 10.1590/S0100-72032004000400008
OBJECTIVE: to assess the concordance of different urodynamic parameters with simplified cystometry, thus improving the cost-benefit relationship for stress urinary incontinence (SUI) diagnosis in woman. METHODS: we evaluated retrospectively the medical records of thirty patients treated, from January 2000 to March 2001. All patients had been submitted to physical and gynecological examinations. A conventional urodynamic study had been made using a Dynograph R-611 recorder. Simplified cystometry had used a saline tube with "Y" connector, connected to a Foley 14 Fr catheter, which allowed measurement of intra-vesical pressure at the same time as physiological saline infusion. The following parameters were analyzed: residual volume, bladder capacity, complacency, involuntary detrusor contractions, and abdominal leak-point pressure. The Pearson test of agreement and the Wilcoxon signed rank test were used to verify the concordance between related samples, with p < 0,05. RESULTS: the average age was 50 years old (28-70). Concordance between studies for stress urinary losses was 67%, and for detrusor involuntary contractions, 90%. The average residual volume was significantly different: by simplified cystometry it was 16.8 ml versus 2 ml by conventional urodynamics (p < 0.01). The average maximum vesical capacity by urodynamic study was 440.5 ml, and by simplified cystometry, 387 ml (p < 0.05). Vesical complacency was on average, significantly larger in simplified cystometry (43.0 ml/cmH2O) than in the urodynamic study (31.5 ml/cmH2O), with p < 0.01. CONCLUSION: preliminary evaluations suggest that the urogynecologic propedeutic associated with cystometry is an option to be considered in the clinical and preoperative assessment of patients with SUI instead of conventional urodynamics, particularly when the latter is not available. Simplified cystometry is an accessible exam that grants comparable results for the detection of involuntary detrusor contractions and for the identification of urinary loss, providing the examiner with trustworthy data on vesical behavior.
Summary
Rev Bras Ginecol Obstet. 2000;22(9):567-572
DOI 10.1590/S0100-72032000000900005
Purpose: to study the repercussion of arterial hypertension regarding body weight gain and body length, as well as liver and brain weight of offspring. Methods: a total of 82 animals in reproductive age were used. They were randomly assigned to 4 different groups (control, handled, nephrectomized and hypertensive). Renal hypertension was produced by a controlled constriction of the main left renal artery and contralateral nephrectomy, according to the technique described by Goldblatt (Goldblatt I: one kidney - one clip hypertension). Afterwards, they were distributed among nonpregnant and pregnant groups. The following newborn groups resulted from the pregnant groups: RN-C (control-newborn group of pregnant rats without surgical treatment), RN-M (manipulation-newborn group of the pregnant rats with surgical manipulation), RN-N (nephrectomized-newborn group of pregnant rats with nephrectomy) and Rn-H (hypertensive-newborn group of pregnant rats with hypertension). Results: the RN-N and RN-H groups showed body weight gain (
= 3,64 ± 0,50; or = 3,37 ± 0,44), body length ( = 3,89 ± 0,36; or = 3,68 ± 0,32) and brain weight ( = 0,16 ± 0,01; or = 0,16 ± 0,05), respectively, smaller than the control group ( = 5,40 ± 0,51; or = 4,95 ± 0,23 and or = 0,22 ± 0,04, respectively). In addition, the RN-H group showed the lowest liver weight ( = 0,22 ± 0,03) compared with the other three groups. Conclusion: after statistical analysis, the results obtained showed that the arterial hypertension determined a reduction in body weight, body length, and liver and brain weight of the offspring.
Summary
Rev Bras Ginecol Obstet. 2000;22(9):567-572
DOI 10.1590/S0100-72032000000900005
Purpose: to study the repercussion of arterial hypertension regarding body weight gain and body length, as well as liver and brain weight of offspring. Methods: a total of 82 animals in reproductive age were used. They were randomly assigned to 4 different groups (control, handled, nephrectomized and hypertensive). Renal hypertension was produced by a controlled constriction of the main left renal artery and contralateral nephrectomy, according to the technique described by Goldblatt (Goldblatt I: one kidney - one clip hypertension). Afterwards, they were distributed among nonpregnant and pregnant groups. The following newborn groups resulted from the pregnant groups: RN-C (control-newborn group of pregnant rats without surgical treatment), RN-M (manipulation-newborn group of the pregnant rats with surgical manipulation), RN-N (nephrectomized-newborn group of pregnant rats with nephrectomy) and Rn-H (hypertensive-newborn group of pregnant rats with hypertension). Results: the RN-N and RN-H groups showed body weight gain ( = 3,64 ± 0,50; or = 3,37 ± 0,44), body length ( = 3,89 ± 0,36; or = 3,68 ± 0,32) and brain weight ( = 0,16 ± 0,01; or = 0,16 ± 0,05), respectively, smaller than the control group ( = 5,40 ± 0,51; or = 4,95 ± 0,23 and or = 0,22 ± 0,04, respectively). In addition, the RN-H group showed the lowest liver weight ( = 0,22 ± 0,03) compared with the other three groups. Conclusion: after statistical analysis, the results obtained showed that the arterial hypertension determined a reduction in body weight, body length, and liver and brain weight of the offspring.
Summary
Rev Bras Ginecol Obstet. 2001;23(2):87-91
DOI 10.1590/S0100-72032001000200005
Purpose: to study the repercussion regarding placental weight and placental index determined by induced experimental hypertension in rats. Methods: a total of 82 rats in reproductive age were used. They were randomly assigned to 4 different groups (control, handled, nephrectomy and hypertension) and renal hypertension was produced by a controlled constriction of the main left renal artery, according to the technique described by Goldblatt, and contralateral nephrectomy (Goldblatt I one kidney--one clip model). Furthermore, they were distributed into non-pregnant groups and pregnant (P) groups. From the pregnant groups, the following newborn groups were obtained: RN-C (control -- newborn group from the pregnant rats without surgical treatment), RN-M (manipulation -- newborn group from the pregnant rats with surgical manipulation), RN-N (nephrectomy -- newborn group from the pregnant rats with nephrectomy) and RN-H (hypertension -- newborn group from pregnant rats with hypertension). Results: the RN-C newborn group (
= 0.58 ± 0,12) showed placental weight higher than the other three groups (RN-M: or = 0.51 ± 0.05; RN-N: or = 0.45 ± 0.07 and RN-H: or = 0.42 ± 0.04). On the other hand, it was possible to observe that the placental weight of the RN-M was higher than that of RN-N and RN-H, respectively, but no difference was observed between the RN-N and RN-H groups. The placental index showed no difference between P-C (Md = 0.1085) and P-M (Md = 0.1110), and also between P-N (0.1175) and P-H (0.1211), but it was observed that the placental indexes of P-C and P-M were smaller that those of P-N and P-H. Conclusion: unilateral nephrectomy and hypertension determined a reduction in placental weight and an increase in the placental index, showing a repercussion regarding placental and fetal development.
Summary
Rev Bras Ginecol Obstet. 2001;23(2):87-91
DOI 10.1590/S0100-72032001000200005
Purpose: to study the repercussion regarding placental weight and placental index determined by induced experimental hypertension in rats. Methods: a total of 82 rats in reproductive age were used. They were randomly assigned to 4 different groups (control, handled, nephrectomy and hypertension) and renal hypertension was produced by a controlled constriction of the main left renal artery, according to the technique described by Goldblatt, and contralateral nephrectomy (Goldblatt I one kidney--one clip model). Furthermore, they were distributed into non-pregnant groups and pregnant (P) groups. From the pregnant groups, the following newborn groups were obtained: RN-C (control -- newborn group from the pregnant rats without surgical treatment), RN-M (manipulation -- newborn group from the pregnant rats with surgical manipulation), RN-N (nephrectomy -- newborn group from the pregnant rats with nephrectomy) and RN-H (hypertension -- newborn group from pregnant rats with hypertension). Results: the RN-C newborn group ( = 0.58 ± 0,12) showed placental weight higher than the other three groups (RN-M: or = 0.51 ± 0.05; RN-N: or = 0.45 ± 0.07 and RN-H: or = 0.42 ± 0.04). On the other hand, it was possible to observe that the placental weight of the RN-M was higher than that of RN-N and RN-H, respectively, but no difference was observed between the RN-N and RN-H groups. The placental index showed no difference between P-C (Md = 0.1085) and P-M (Md = 0.1110), and also between P-N (0.1175) and P-H (0.1211), but it was observed that the placental indexes of P-C and P-M were smaller that those of P-N and P-H. Conclusion: unilateral nephrectomy and hypertension determined a reduction in placental weight and an increase in the placental index, showing a repercussion regarding placental and fetal development.
