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Liposarcoma is a rare neoplasia that originates from primitive mesenchymal cells and is the most common histological type of sarcoma. It mainly affects the limbs but can reach other regions. Genital localization is, however, rare. The authors report a case of vulvar liposarcoma in a 27-year-old patient, who presented a progressively growing mass that limited her movements. Physical examination showed a large ulcerated vulvar tumor. The patient underwent local resection and histopathological examination diagnosed a well-differentiated liposarcoma with uncompromised margins. At the present time, 24 months after surgery, the patient is well and without recurrence of the disease.