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  • Original Article

    Clinical Characteristics and Outcomes of a High-grade Endometrial Cancer Cohort Treated at Instituto Nacional de Câncer, Brazil

    Revista Brasileira de Ginecologia e Obstetrícia. 2023;45(7):401-408

    Summary

    Original Article

    Clinical Characteristics and Outcomes of a High-grade Endometrial Cancer Cohort Treated at Instituto Nacional de Câncer, Brazil

    Revista Brasileira de Ginecologia e Obstetrícia. 2023;45(7):401-408

    DOI 10.1055/s-0043-1772177

    Views8

    Abstract

    Objective

    To analyze the outcomes of a cohort of patients with high-risk histologies of endometrial cancer (EC) treated at Instituto Nacional de Câncer (National Cancer Institute, INCA, in Portuguese), in Brazil.

    Materials and Methods

    We reviewed the medical records of patients with high-risk histologies of EC in any stage registered at INCA between 2010 and 2016 to perform a clinical and demographic descriptive analysis and to evaluate the outcomes in terms of recurrence and survival.

    Results

    From 2010 to 2016, 2,145 EC patients were registered and treated at INCA, and 466 had high-grade histologies that met the inclusion criteria. The mean age of the patients was 65 years, 44.6% were Caucasian, and 90% had a performance status of 0 or 1. The most common histology was high-grade endometrioid (31.1%), followed by serous carcinoma (25.3%), mixed (20.0%), carcinosarcoma (13.5%), and clear cell carcinoma (9.4%). Considering the 2018 Fédération Internationale de Gynécologie et d'Obstétrique (International Federation of Gynecology and Obstetrics, FIGO, in French) staging system, 44.8%, 12.4%, 29.8%, and 12.9% of the patient were in stages I, II, III or IV respectively. Age (> 60 years), more than 50% of myoinvasion, higher stage, poor performance status, serous and carcinosarcoma histologies, and adjuvant treatment were independent factors associated with recurrence-free survival (RFS) and overall survival (OS) in the multivariate analysis.

    Conclusion

    The current findings reinforced the international data showing poor outcomes of these tumors, especially for serous and carcinosarcomas and tumors with advanced stages, with shorter survival and high recurrence rates in distant sites, independently of the FIGO stage. Adjuvant therapy was associated with better survival.

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  • Letter to Editor

    Advanced Cervical Cancer: Leveraging the Historical Threshold of Overall Survival

    Revista Brasileira de Ginecologia e Obstetrícia. 2021;43(3):235-237

    Summary

    Letter to Editor

    Advanced Cervical Cancer: Leveraging the Historical Threshold of Overall Survival

    Revista Brasileira de Ginecologia e Obstetrícia. 2021;43(3):235-237

    DOI 10.1055/s-0041-1728662

    Views3
    Dear Editor, Cervical cancer is a public health problem in low- and middle-income countries, where many patients are diagnosed at an advanced stage. After the Gynecology Oncology Group (GOG) 240 study, the first-line standard of care for patients in recurrent and/or metastatic settings includes the incorporation of bevacizumab with chemotherapy. Regarding the second line, no […]
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    Advanced Cervical Cancer: Leveraging the Historical Threshold of Overall Survival

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