Summary
Summary
Revista Brasileira de Ginecologia e Obstetrícia. 2006;28(9):551-556
DOI 10.1590/S0100-72032006000900008
Premature ovarian failure may be idiopathic or associated with several autoimmune and genetic disorders as X chromosome deletions. We report two cases of preamture ovarian failure associated with a deletion in the long arm of X chromosome. Both patients were nulligravidas presenting secondary amenorrhea and complaints of infertility, without family history of premature ovarian failure and reporting normal puberal development. Their karyotypes showed deletions of the distal long arm of all X chromosomes and were 46,X, del(Xq22) and 46,X, del(Xq13q28), respectively. After the diagnosis the patients decided to be submitted to an in vitro fertilization with egg donation.
Summary
Revista Brasileira de Ginecologia e Obstetrícia. 2006;28(9):565-565
Summary
Revista Brasileira de Ginecologia e Obstetrícia. 2006;28(9):509-510
Summary
Revista Brasileira de Ginecologia e Obstetrícia. 2006;28(9):513-522
DOI 10.1590/S0100-72032006000900003
PURPOSE: to describe, in participants of the Brazilian Study of Gestational Diabetes (EBDG), the percentile distribution of uterine height by gestational age and to validate the use of percentiles of the chart derived by the "Centro Latino-Americano de Perinatologia" (CLAP), used as reference in predicting abnormal fetal growth. METHODS: the EBDG is a cohort study of 5564 pregnant women older than 19 years, followed through and after delivery. Interviews and standardized anthropometry were performed at baseline between 20-28 weeks. Medical records covering prenatal and delivery periods were then reviewed following a standardized approach. Analyses pertain to 3539 women with gestational age confirmed by ultrasound. Diagnostic properties of the 10th and the 90th percentiles of both charts (EBDG and CLAP) as predictors of abnormal neonatal weight were determined. RESULTS: uterine height was higher in EBDG than in the CLAP chart at every gestational week, being 1-4 and 2-6 cm greater, at the 10th and 90th percentiles respectively. The CLAP 10th percentile classified as small the uterine heights of only 0.3 to 1.7% of Brazilian women, while the 90th percentile classified as large the uterine heights of 42 to 57% of the sample. The sensitivity of CLAP percentile 10 in the prediction of small for gestational age varied from 0.8 to 6% and the specificity of CLAP percentile 90 in the prediction of large for gestational age, from 46 to 61%. CONCLUSIONS: the CLAP uterine height reference chart does not reflect the current uterine growth pattern of pregnant Brazilians, limiting its clinical applicability in the detection of abnormal fetal growth, especially intrauterine growth restriction.
Summary
Revista Brasileira de Ginecologia e Obstetrícia. 2006;28(9):523-529
DOI 10.1590/S0100-72032006000900004
PURPOSE: to determine the values of perineal muscular force (PMF) in the lying and seated positions and to identify the values of PMF between first pregnancy, according to type and the characteristics of the vaginal delivery and cesarean section. METHODS: study of the transversal type, performed in a maternity of Brazilian Public the Health System (SUS) in the city of São Paulo. The sample consisted of 95 primiparae at term. Evaluation occurred between the 40th and 45 th, day with an interview, physical examination and measurement of PMF using a perineometer of the Kegel type. The measurement was carried out in the lying and seated positions, muscular status (at rest and in maximum contraction), and the average of three measures for each position and muscular state were considered. RESULTS: 76.8% (73) of the women had vaginal delivery and 23.2% (22) cesarean section. After vaginal delivery, intact perineum in 18.9%, (18), perineal rupture in 24.2% (23), and episiotomy in 33.7% (32) were observed. Obtained values of the PMF were: lying position muscular rest 18. 9 mmHg, lying position maximum contraction: 30,7 mmHg, seated position muscular rest: 34.5 mmHg, seated positions maximum muscular contraction: 46.5 mmHg. CONCLUSION: there was association between the type and the characteristics of the delivery and PMF.
Summary
Revista Brasileira de Ginecologia e Obstetrícia. 2006;28(9):530-535
DOI 10.1590/S0100-72032006000900005
PURPOSE: to compare the incidence of preterm deliveries, and of low birth weight newborns, among primiparous adolescents, from two age groups. METHODS: this is a comparative, cross-sectional clinical study composed of 522 primiparous adolescents whose deliveries occurred at the gestational age of 25 to 42 weeks. The adolescents were divided into 2 groups according to their age; Gprec: from 10 to 15 complete years old (n=104); Gtard: from 16 to 19 complete years old (n=418). The research data were obtained by an individualized, confidential and ethical interview, soon after delivery; and by a written questionnaire with questions about the gestational age in complete weeks, and about the newborns birth weight. The gestational age was calculated at the delivery day, according to the date of the last trustworthy menstrual period, being also confirmed by the earliest pregnancy scanning or by Capurro's index, when there were any doubts about the previously described parameters. All newborns with gestational age under 37 weeks at birth were considered preterm babies. The newborn weight was taken by neonatologists immediately after delivery; all newborns with less than 2,500g were considered to be low weight babies. Thus, we compared prematurity rate and low birth weight among newborns from primiparous puerperal adolescents. The chi² test was used for the statistic analysis and the partition chi² test for the found differences. As the significancy level was 0.05 (alpha =5%), lower levels than that were considered significant. RESULTS: the prematurity rate was not significantly different between the two groups (5.8 and 2.6%). The incidence of low birth weight in Gprec (13.5%) was significantly higher than in Gtard (3.1%). CONCLUSIONS: the group with primiparous adolescents under 15 years old showed a significantly higher risk of low birth weight newborns. However, a statistically significant incidence of prematurity between the groups studied was not verified.
Summary
Revista Brasileira de Ginecologia e Obstetrícia. 2006;28(9):536-544
DOI 10.1590/S0100-72032006000900006
PURPOSE: to evaluate risk factors associated with cervical intraepithelial lesion recurrence after LEEP conization. METHODS: nested case-control study in a cohort of 201 patients with cervical intraepithelial lesion, that were submitted to LEEP conization. Average follow-up of these patients was 2 years. Ninety-four HIV-infected women and 107 non-infected were enrolled. Cervical conization was achieved by the Loop Electrosurgical Excision Procedure (LEEP). Evaluated surgical biopsy histopathological characteristics were lesion grade, lesion borders and glandular involvement. After surgery all patients were submitted to a colposcopy and cytological evaluation every six months. Recurrent lesions were defined it confirmed by biopsy after surgery. Cases were patients with and controls patients without recurrence. chi2 test and multivariable analysis by logistic regression were used for group comparisons. Kaplan Meier's method was performed for the survival analyses (log-rank test). RESULTS: 40 patients had lesion recurrence. Initially, significant variables were: partner number, HIV-infection, lesion borders and glandular involvement. The most frequent recurrence occurred when there were simultaneous association between positive margins and glandular involvement as indicator for recurrence risk. After logistic regression analysis the main factors associated with lesion recurrence were: glandular involvement (OR-9.1; 95% CI:13.0- 27.5); HIV-infection (OR-4.6; 95% IC:1.1-6.3); compromised margins (OR-2.6; 95% IC:1.9-11.2). CONCLUSIONS: risk factors associated with cervical intraepitelial lesion recurrence were HIV-infection, glandular involvement and compromised margins.