Você pesquisou por y?yr=2014 - Revista Brasileira de Ginecologia e Obstetrícia

8 articles
  • Editorial

    How the gynecologist can guide women with a family history of cancer?

    Revista Brasileira de Ginecologia e Obstetrícia. 2014;36(8):335-339

    Summary

    Editorial

    How the gynecologist can guide women with a family history of cancer?

    Revista Brasileira de Ginecologia e Obstetrícia. 2014;36(8):335-339

    DOI 10.1590/SO100-720320140005104

    Views2
    A postagem não tem conteúdo
    See more
    How the gynecologist can guide women with a family history of cancer?
  • Artigos Originais

    Loss of PTEN expression and AKT activation in HER2-positive breast carcinomas

    Revista Brasileira de Ginecologia e Obstetrícia. 2014;36(8):340-346

    Summary

    Artigos Originais

    Loss of PTEN expression and AKT activation in HER2-positive breast carcinomas

    Revista Brasileira de Ginecologia e Obstetrícia. 2014;36(8):340-346

    DOI 10.1509/SO100-720320140005034

    Views0

    PURPOSE:

    To examine the expression of AKT and PTEN in a series of HER2-positive primary invasive breast tumors using immunohistochemistry, and to associate these expression profiles with classic pathologic features such as tumor grade, hormone receptor expression, lymphatic vascular invasion, and proliferation.

    METHODS:

    A total of 104 HER2-positive breast carcinoma specimens were prepared in tissue microarrays blocks for immunohistochemical detection of PTEN and phosphorylated AKT (pAKT). Original histologic sections were reviewed to assess pathological features, including HER2 status and Ki-67 index values. The associations between categorical and numeric variables were identified using Pearson's chi-square test and the Mann-Whitney, respectively.

    RESULTS:

    Co-expression of pAKT and PTEN was presented in 59 (56.7%) cases. Reduced levels of PTEN expression were detected in 20 (19.2%) cases, and these 20 tumors had a lower Ki-67 index value. In contrast, tumors positive for pAKT expression [71 (68.3%)] were associated with a higher Ki-67 index value.

    CONCLUSION:

    A role for AKT in the proliferation of HER2-positive breast cancers was confirmed. However, immunohistochemical detection of PTEN expression did not correlate with an inhibition of cellular proliferation or control of AKT phosphorylation, suggesting other pathways in these mechanisms of control.

    See more
    Loss of PTEN expression and AKT activation in HER2-positive breast carcinomas
  • Artigos Originais

    Validity of cervicovaginal cytology in a Brazilian State with high incidence rate of cervical cancer

    Revista Brasileira de Ginecologia e Obstetrícia. 2014;36(8):347-352

    Summary

    Artigos Originais

    Validity of cervicovaginal cytology in a Brazilian State with high incidence rate of cervical cancer

    Revista Brasileira de Ginecologia e Obstetrícia. 2014;36(8):347-352

    DOI 10.1590/SO100-720320140005061

    Views1

    PURPOSE:

    To evaluate the validity of cervicovaginal cytology performed at LAPER, the main Laboratory of Pathology of the State of Roraima, Brazil, by interrater agreement (external monitoring) and agreement with histopathologic results.

    METHODS:

    One hundred women were included, a population-based convenience sample. Their cervical cytological exams were evaluated by the laboratory staff and reviewed by expert medical pathologists, external to the laboratory. Cohen's Kappa index, sensitivity and specificity were evaluated. The study was approved by LAPER coordination and Federal University of Roraima Research Ethics Commitee.

    RESULTS:

    Regarding the prevalence of human papillomavirus-related atypical, there was no concordance between the results issued by LAPER and by the external pathologists (k=0.21). A low sensitivity (28.5%) and specificity (89,2%) was detected for the diagnostic performance of LAPER, with a high proportion of false positive and false negative results. The cytological reports of the external pathologists showed higher sensitivity and specificity (71.4 and 98.9%, respectively), ruling out the possibility that errors related to collection methods and staining would explain the low performance of the laboratory.

    CONCLUSION:

    A low diagnostic accuracy of cervicovaginal cytology can be a barrier against the control of cervical cancer in Roraima. We emphasize the need for professional training and internal and external monitoring in Brazilian states with a high incidence of cervical cancer.

    See more
  • Artigos Originais

    Effects of hyperprolactinemia and ovariectomy on the tibial epiphyseal growth plate and bone formation in mice

    Revista Brasileira de Ginecologia e Obstetrícia. 2014;36(8):359-366

    Summary

    Artigos Originais

    Effects of hyperprolactinemia and ovariectomy on the tibial epiphyseal growth plate and bone formation in mice

    Revista Brasileira de Ginecologia e Obstetrícia. 2014;36(8):359-366

    DOI 10.1590/SO100-720320140005065

    Views0

    PURPOSE:

    To evaluate the effects of ovariectomy and the hyperprolactinemia procedure in the tibial epiphyseal growth plate of female mice.

    METHODS:

    In this study, the epiphyseal growth plate of ovariectomized (OVX) and/or rendered hyperprolactinemic female mice by 50 days of treatment with 200 μg metoclopramide (M) was evaluated morphologically, morphometrically and immuno-histochemically. Forty female and adult mice were divided into four groups according to treatment: V group - animals treated with saline solution; H group - hyperprolactinemic animals; Ovx/V group - ovariectomized animals and treated with saline solution; Ovx/H group - hyperprolactinemic and ovariectomized animals. After the treatment period, the animals were sacrificed, tibia was removed and fixed in 10% buffered formalin and decalcified in 10% formic acid. The material was immersed in paraffin and subjected to histological processing in paraffin. The sections were stained with Masson's trichrome and immunohistochemistry was carried out for the pro-apoptotic protein BCL-2. The images for the morphological and morphometric study were analyzed with the imaging program AxioVision 4.8 (Carl-Zeiss(r), Germany).

    RESULTS:

    The combination of hyperprolactinemia and the ovariectomy procedure decreased the number of resting chondrocytes 1.5-fold, the number of proliferative chondrocytes 1.8-fold; the percentage of resting cartilage 2.4-fold and the percentage of trabecular bone 2.1-fold, compared with respective control animals.

    CONCLUSION:

    The procedure of ovariectomy combined with the metoclopramide-induced hyperprolactinemia in female mice has showed marked bone degeneration due to significant decrease of cell proliferation in the epiphyseal growth plate and bone formation.

    See more
    Effects of hyperprolactinemia and ovariectomy on the tibial epiphyseal growth plate and bone formation in mice
  • Artigos Originais

    Breast and cervical cancer in patients with systemic lupus erythematosus

    Revista Brasileira de Ginecologia e Obstetrícia. 2014;36(8):367-371

    Summary

    Artigos Originais

    Breast and cervical cancer in patients with systemic lupus erythematosus

    Revista Brasileira de Ginecologia e Obstetrícia. 2014;36(8):367-371

    DOI 10.1590/SO100-720320140005052

    Views1

    PURPOSE:

    To study the incidence of tumors in a Brazilian sample of women with systemic lupus erythematosus.

    METHODS:

    This is a retrospective study of 395 medical charts from women with systemic lupus erythematosus diagnosed by the presence of at least 4 of the American College of Rheumatology classification criteria for the diagnosis of this disease and followed for the last 10 years in a rheumatology outpatient clinic. Demographic data (age and ethnicity of patients), data on disease duration, use of immunomodulators and on the presence of neoplasms were listed. Results are presented in frequency and contingency tables. The incidence rate of malignancies in women with lupus was compared with that of the general population for the same demographic region for the past ten years, using data published by the Brazilian National Cancer Institute (INCA). Association studies were carried out by the Fisher and χ tests, when the data were nominal, and by Mann-Whitney test, when numeric. The level of significance was set at 5%.

    RESULTS:

    Twenty-two cases of malignant tumors were identified during these 10 years of follow-up (22 cases/395 or 5.5% of the sample), being the most common those of the uterine cervix (10 cases/395 or 2.5% of the sample) and breast cancer (9 cases/395 or 2.2% of the sample). The presence of tumors was associated with disease duration (p=0.006) and was not influenced by treatment with methotrexate (p=0.1), azathioprine (p=0.9), cyclophosphamide (p=0.6) and glucocorticoids (p=0.3). Breast and uterine cervix tumors were more common in systemic lupus erythematosus women than in the general population (p<0.0001 for both).

    CONCLUSION:

    A high prevalence of malignant tumors was found in this sample, with tumors being more common in patients with longer disease duration. The most frequent tumors affected the breast and uterus at a higher incidence than in the general population. The presence of tumors was not influenced by the use of glucocorticoids or immunosuppressors.

    See more
    Breast and cervical cancer in patients with systemic lupus erythematosus
  • Artigos Originais

    Comparison between the serum concentration of alpha-tocopherol in puerperal women assisted in public and private maternities in Northeastern Brazil

    Revista Brasileira de Ginecologia e Obstetrícia. 2014;36(8):372-376

    Summary

    Artigos Originais

    Comparison between the serum concentration of alpha-tocopherol in puerperal women assisted in public and private maternities in Northeastern Brazil

    Revista Brasileira de Ginecologia e Obstetrícia. 2014;36(8):372-376

    DOI 10.1590/SO100-720320140005006

    Views0

    PURPOSE:

    To compare the concentration of serum alpha-tocopherol during the postpartum period in women admitted to public and private hospitals in Natal (RN), Brazil.

    METHODS:

    The study included 209 women in the postpartum period, 96 of them from private hospitals and 113 from public hospitals, studied between 24 and 48 hours postpartum. Inclusion criteria were: mothers aged 12 years or more, without diseases associated with pregnancy, who had given birth to a singleton with no malformations. Clinically decompensated women with multiple fetuses were excluded. A 5 mL blood sample was obtained from each participant under fasting conditions, before the first meal of the day. The concentration of alpha-tocopherol in serum (µg/dL) was determined by high performance liquid chromatography (HPLC). The statistical difference between means was tested by the Student's t-test.

    RESULTS:

    The mean concentration of alpha-tocopherol was 1.115.7 µg/dL in puerperae from the public network and 1.355.7±397.6 µg/dL in puerperae from the privte network , with a significant difference between groups (p=0.000687). Vitamin E concentration was determined individually and an alpha-tocopherol level <11.6 µmol/L or <499.6 µg/dL was considered to indicate deficiency. Vitamin E deficiency was detected in 5.3% of puerperae from the public network (n=6), whereas no deficiency was detected among women from the private network. However, low concentrations of alpha-tocopherol (11.6 to 16.2 µmol/L or 499.6 to 697.7 µg/dL) was detected in both groups, i.e., in 9.7% of the women from the public network (n=11) and in 4.2% for the women from the private network (n=4).

    CONCLUSION:

    These results highlight that women assisted in the public sector were more vulnerable to developing low concentrations of alpha-tocopherol than women assisted in the private sector.

    See more
  • Case Report

    Spontaneous rupture of renal angiomyolipoma during pregnancy

    Revista Brasileira de Ginecologia e Obstetrícia. 2014;36(8):377-380

    Summary

    Case Report

    Spontaneous rupture of renal angiomyolipoma during pregnancy

    Revista Brasileira de Ginecologia e Obstetrícia. 2014;36(8):377-380

    DOI 10.1590/SO100-720320140005019

    Views10

    Renal angiomyolipoma is a benign tumor, composed of adipocytes, smooth muscle cells and blood vessels. The association with pregnancy is rare and related with an increased risk of complications, including rupture with massive retroperitoneal hemorrhage. The follow-up is controversial because of the lack of known cases, but the priorities are: timely diagnosis in urgent cases and a conservative treatment when possible. The mode of delivery is not consensual and should be individualized to each case. We report a case of a pregnant woman with 18 weeks of gestation admitted in the emergency room with an acute right low back pain with no other symptoms. The diagnosis of rupture of renal angiomyolipoma was established by ultrasound and, due to hemodinamically stability, conservative treatment with imaging and clinical monitoring was chosen. At 35 weeks of gestation, it was performed elective cesarean section without complications for both mother and fetus.

    See more
    Spontaneous rupture of renal angiomyolipoma during pregnancy
  • Resumo De Tese

    HOXA10 as well as estrogen and progesterone receptor protein expression in the epithelium, stroma, and adjacent smooth muscle of rectosigmoid endometriosis

    Revista Brasileira de Ginecologia e Obstetrícia. 2014;36(8):381-381

    Summary

    Resumo De Tese

    HOXA10 as well as estrogen and progesterone receptor protein expression in the epithelium, stroma, and adjacent smooth muscle of rectosigmoid endometriosis

    Revista Brasileira de Ginecologia e Obstetrícia. 2014;36(8):381-381

    DOI 10.1590/SO100-72032014T0002

Search

Search in:

Article type
abstract
book-review
brief-report
case-report
case-report -
correction
editorial
editorial -
letter
letter -
other
other -
rapid-communication
research-article
research-article -
review-article
review-article -
Section
Arigos Originais
Artigo de Revisão
Original Articles
Carta ao Editor
Carta ao Editor
Cartas
Case Report
Case Reports
Caso e Tratamento
Clinical Consensus Recommendation
Corrigendum
Editoriais
Editorial
Editorial
Equipamentos e Métodos
Errata
Erratas
Erratum
Febrasgo Position Statement
Febrasgo Statement
Febrasgo Statement Position
FIGO Statement
GUIDELINES
Integrative Review
Letter to Editor
Letter to Editor
Letter to the Editor
Letter to the Editor
Métodos e Técnicas
Nota do Editor
Nota Prévia
Original Article
Original Article/Contraception
Original Article/Infertility
Original Article/Obstetrics
Original Article/Oncology
Original Article/Sexual Violence/Pediatric and Adolescent Gynecology
Original Article/Teaching and Training
Original Articles
Original Articles
Relato de Caso
Relato de Casos
Relatos de Casos
Reply to the Letter to the Editor
Resposta dos Autores
Resumo De Tese
Resumo De Tese
Resumos de Tese
Resumos de Tese
Resumos de Teses
Resumos de Teses
Resumos dos Trabalhos Premiados no 50º Congresso Brasileiro de Ginecologia e Obstetrícia
Review
Review Article
Review Articles
Revisão
Revisão
Short Communication
Special Article
Systematic Review
Técnica e Equipamentos
Técnicas e Equipamentos
Técnicas e Métodos
Trabalhos Originais
Year / Volume
2024; v.46
2023; v.45
2022; v.44
2021; v.43
2020; v.42
2019; v.41
2018; v.40
2017; v.39
2016; v.38
2015; v.37
2014; v.36
2013; v.35
2012; v.34
2011; v.33
2010; v.32
2009; v.31
2008; v.30
2007; v.29
2006; v.28
2005; v.27
2004; v.26
2003; v.25
2002; v.24
2001; v.23
2000; v.22
1999; v.21
1998; v.20
ISSUE
Todas
1
2
3
4
5
6
7
8
9
10
11
12