Paroxysmal nocturnal hemoglobinuria in pregnancy - Revista Brasileira de Ginecologia e Obstetrícia

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Case Report

Paroxysmal nocturnal hemoglobinuria in pregnancy

Rev Bras Ginecol Obstet. 2004;26(7):579-582

DOI: 10.1590/S0100-72032004000700011

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Paroxysmal nocturnal hemoglobinuria is a rare disease caused by an acquired gene mutation of the hematopoietic system, with 16-18% of the cases diagnosed during pregnancy. We describe two cases of pregnancy in women with paroxysmal nocturnal hemoglobinuria. Maternal mortality reaches 8-10%, mainly due to thromboembolism and, less frequently, to leukemic transformation. Fetal losses may reach 30%. These two cases illustrate a serious and extremely complex situation, which is the obstetrical management of a patient with a very rare, serious and potentially fatal hematological condition. Using a multidisciplinary approach in tertiary care centers, it is possible to attain good maternal and perinatal outcomes.

Key-words Hemoglobinuria Medullary aplasia Pregnancy complications

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EndNote RIS

Electronic Document Format (Vancouver)

Nomura ML, Surita FGC, Parpinelli MA, Carvalho ECC, Passini Júnior R. Paroxysmal nocturnal hemoglobinuria in pregnancy. Rev Bras Ginecol Obstet 2004;26(7):579-82.

Electronic Document Format (ABNT)

Nomura, Marcelo Luís; Surita, Fernanda Garanhani de Castro; Parpinelli, Mary Angela; Carvalho, Egle Cristina Couto; Passini Júnior, Renato. Paroxysmal nocturnal hemoglobinuria in pregnancy. Rev Bras Ginecol Obstet, v. 26, n. 7, p. 579-582, Oct. 2004.

Electronic Document Format (APA)

Nomura, M. L., Surita, F. G. C., Parpinelli, M. A., Carvalho, E. C. C., & Passini Júnior, R. (2004). Paroxysmal nocturnal hemoglobinuria in pregnancy. Rev Bras Ginecol Obstet, 26(7), 579-582.

Electronic Document Format (ISO)

Nomura, Marcelo Luís and Surita, Fernanda Garanhani de Castro and Parpinelli, Mary Angela and Carvalho, Egle Cristina Couto and Passini Júnior, Renato. Paroxysmal nocturnal hemoglobinuria in pregnancy. Rev Bras Ginecol Obstet [online]. 2004, vol. 26, n. 7, [cited 2024-06-28], pp.579-582. Available from: <https://journalrbgo.org/article/paroxysmal-nocturnal-hemoglobinuria-in-pregnancy/>.
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Paroxysmal nocturnal hemoglobinuria in pregnancy |

Paroxysmal nocturnal hemoglobinuria is a rare disease caused by an acquired gene mutation of the hematopoietic system, with 16-18% of the cases diagnosed during pregnancy. We describe two cases of pregnancy in women with paroxysmal nocturnal hemoglobinuria. Maternal mortality reaches 8-10%, mainly due to thromboembolism and, less frequently, to leukemic transformation. Fetal losses may reach 30%. These two cases illustrate a serious and extremely complex situation, which is the obstetrical management of a patient with a very rare, serious and potentially fatal hematological condition. Using a multidisciplinary approach in tertiary care centers, it is possible to attain good maternal and perinatal outcomes.