Human Papillomavirus 16 Lineage D is Associated with High Risk of Cervical Cancer in the Brazilian Northeast Region - Revista Brasileira de Ginecologia e Obstetrícia

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Original Article

Human Papillomavirus 16 Lineage D is Associated with High Risk of Cervical Cancer in the Brazilian Northeast Region

Rev Bras Ginecol Obstet. 2023;45(8):474-479

DOI: 10.1055/s-0043-1772180

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Abstract

Objective

Similar to Human Papillomavirus (HPV) genotypes, different lineages of a genotype also have different carcinogenic capabilities. Studies have shown that specific genotype lineages of oncogenic HPV are associated with variable risks for the development of cervical intraepithelial neoplasia (CIN2/CIN3) and cervical cancer. The present study aimed to analyze the genetic diversity of the HPV16 genotype in women with CIN2/CIN3 and cervical cancer, from the northeast region of Brazil.

Methods

A cross-sectional multicenter study was conducted in the northeast region of Brazil, from 2014 to 2016. This study included 196 cases of HPV16 variants (59 and 137 cases of CIN2/CIN3 and cervical cancer, respectively). The difference of proportion test was used to compare patients with CIN2/CIN3 and cervical cancer, based on the prevalent HPV16 lineage (p < 0.05).

Results

According to the histopathological diagnosis, the percentage of lineage frequencies revealed a marginal difference in the prevalence of lineage A in CIN2/CIN3, compared with that in cervical cancer (p = 0.053). For lineage D, the proportion was higher in cancer cases (32.8%), than in CIN2/CIN3 cases (16.9%), with p = 0.023.

Conclusion

HPV16 lineage A was the most frequent lineage in both CIN2/CIN3 and cervical cancer samples, while lineage D was predominant in cervical cancer, suggesting a possible association between HPV16 lineage D and cervical cancer.

Key-words cervical cancer CIN2/CIN3 HPV16 lineage A lineage D

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Abstracts of Awarded Papers at the 50th Brazilian Congress of Gynecology and Obstetrics
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Case Report and Treatment
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2014; v.36
2013; v.35
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2009; v.31
2008; v.30
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EndNote RIS

Electronic Document Format (Vancouver)

Martins LFL, Moreira MM, Pinto RA, Reis NB, Felix SP, Vidal JPCB, Torres LC, et al. Human Papillomavirus 16 Lineage D is Associated with High Risk of Cervical Cancer in the Brazilian Northeast Region. Rev Bras Ginecol Obstet 2023;45(8):474-9.

Electronic Document Format (ABNT)

Martins, Luís Felipe Leite; Moreira, Miguel Ângelo Martins; Pinto, Rodrigo Alves; Reis, Neilane Bertoni dos; Felix, Shayany Pinto; Vidal, João Paulo Castello Branco; Torres, Leuridan Cavalcante; Souza, Ariani Impieri; Almeida, Liz Maria de. Human Papillomavirus 16 Lineage D is Associated with High Risk of Cervical Cancer in the Brazilian Northeast Region. Rev Bras Ginecol Obstet, v. 45, n. 8, p. 474-479, Oct. 2023.

Electronic Document Format (APA)

Martins, L. F. L., Moreira, M. M., Pinto, R. A., Reis, N. B. , Felix, S. P., Vidal, J. P. C. B., Torres, L. C., Souza, A. I., & Almeida, L. M. (2023). Human Papillomavirus 16 Lineage D is Associated with High Risk of Cervical Cancer in the Brazilian Northeast Region. Rev Bras Ginecol Obstet, 45(8), 474-479.

Electronic Document Format (ISO)

Martins, Luís Felipe Leite and Moreira, Miguel Ângelo Martins and Pinto, Rodrigo Alves and Reis, Neilane Bertoni dos and Felix, Shayany Pinto and Vidal, João Paulo Castello Branco and Torres, Leuridan Cavalcante and Souza, Ariani Impieri and Almeida, Liz Maria de. Human Papillomavirus 16 Lineage D is Associated with High Risk of Cervical Cancer in the Brazilian Northeast Region. Rev Bras Ginecol Obstet [online]. 2023, vol. 45, n. 8, [cited 2024-06-26], pp.474-479. Available from: <https://journalrbgo.org/article/human-papillomavirus-16-lineage-d-is-associated-with-high-risk-of-cervical-cancer-in-the-brazilian-northeast-region/>.
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Human Papillomavirus 16 Lineage D is Associated with High Risk of Cervical Cancer in the Brazilian Northeast Region |

Abstract

Objective

Similar to Human Papillomavirus (HPV) genotypes, different lineages of a genotype also have different carcinogenic capabilities. Studies have shown that specific genotype lineages of oncogenic HPV are associated with variable risks for the development of cervical intraepithelial neoplasia (CIN2/CIN3) and cervical cancer. The present study aimed to analyze the genetic diversity of the HPV16 genotype in women with CIN2/CIN3 and cervical cancer, from the northeast region of Brazil.

Methods

A cross-sectional multicenter study was conducted in the northeast region of Brazil, from 2014 to 2016. This study included 196 cases of HPV16 variants (59 and 137 cases of CIN2/CIN3 and cervical cancer, respectively). The difference of proportion test was used to compare patients with CIN2/CIN3 and cervical cancer, based on the prevalent HPV16 lineage (p < 0.05).

Results

According to the histopathological diagnosis, the percentage of lineage frequencies revealed a marginal difference in the prevalence of lineage A in CIN2/CIN3, compared with that in cervical cancer (p = 0.053). For lineage D, the proportion was higher in cancer cases (32.8%), than in CIN2/CIN3 cases (16.9%), with p = 0.023.

Conclusion

HPV16 lineage A was the most frequent lineage in both CIN2/CIN3 and cervical cancer samples, while lineage D was predominant in cervical cancer, suggesting a possible association between HPV16 lineage D and cervical cancer.