Authors' reply - Revista Brasileira de Ginecologia e Obstetrícia
Rev Bras Ginecol Obstet. 2022;44(11):1079-1079
Spontaneous abortion is the most frequent adverse outcome in pregnancy, with a rate of 10% to 20% of all pregnancies. In Brazil, the rate of abortion before the COVID-19 pandemic was of 3.5%. In our study, we observed 24 miscarriages after 678,025 doses of COVID-19 vaccines had been administered in pregnant women in Brazil, which corresponds to an incidence of 3.5 cases per 100,000 doses. Such incidence is lower than the postvaccination rate of abortion related to COVID-19 vaccines described by Trostle et al. and much lower than the historical 3.5% expected rate in Brazil.
Our study was observational and used passive surveillance data. Such studies cannot describe the exact rates of abortion in vaccinated pregnant women. Nonetheless, given the historical rates in Brazil, the expected number of abortions in 678,025 normal pregnancies would be 23,731, which averages out to 616 abortions per week of observation. Even if we consider reporting rates lower than 5%, our incidence of abortions would still be far below the expected.
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Spontaneous abortion is the most frequent adverse outcome in pregnancy, with a rate of 10% to 20% of all pregnancies. In Brazil, the rate of abortion before the COVID-19 pandemic was of 3.5%. In our study, we observed 24 miscarriages after 678,025 doses of COVID-19 vaccines had been administered in pregnant women in Brazil, which corresponds to an incidence of 3.5 cases per 100,000 doses. Such incidence is lower than the postvaccination rate of abortion related to COVID-19 vaccines described by Trostle et al. and much lower than the historical 3.5% expected rate in Brazil.
Our study was observational and used passive surveillance data. Such studies cannot describe the exact rates of abortion in vaccinated pregnant women. Nonetheless, given the historical rates in Brazil, the expected number of abortions in 678,025 normal pregnancies would be 23,731, which averages out to 616 abortions per week of observation. Even if we consider reporting rates lower than 5%, our incidence of abortions would still be far below the expected.
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