Antenatal Corticosteroid Administration for Reducing the Risk of Neonatal Morbidities from Prematurity - Revista Brasileira de Ginecologia e Obstetrícia
Revista Brasileira de Ginecologia e Obstetrícia. 2016;38(3):117-119
Prematurity continues to be the most important cause of neonatal complications, with more-severe outcomes with lower gestational age at birth. A recently published multicenter study conducted in the United States analyzed births that occurred between 2000 and 2011 and found that one in every four extreme preterms (< 28 weeks) died before hospital discharge. Deaths that occurred in the first 12h were attributed to generalized immaturity; between 12h and 14 days of life, to respiratory distress syndrome (RDS); and between 15 days and 60 days of life, to necrotizing enterocolitis. This emphasizes the important contribution of prematurity to more-severe outcomes.
Even today, the prevention of prematurity is a major challenge not only because of its multifactorial nature but also because the various causes are not subject to prevention. Thus, when premature delivery is inevitable, the use of antenatal corticosteroids is the only effective intervention for reducing neonatal complications such as RDS, intracranial hemorrhage, necrotizing enterocolitis, and death. However, many misconceptions arise in this area, and hasty conclusions and contradictory information are frequent. These often arise from studies that do not allow to draw the conclusions that are proclaimed.
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Prematurity continues to be the most important cause of neonatal complications, with more-severe outcomes with lower gestational age at birth. A recently published multicenter study conducted in the United States analyzed births that occurred between 2000 and 2011 and found that one in every four extreme preterms (< 28 weeks) died before hospital discharge. Deaths that occurred in the first 12h were attributed to generalized immaturity; between 12h and 14 days of life, to respiratory distress syndrome (RDS); and between 15 days and 60 days of life, to necrotizing enterocolitis. This emphasizes the important contribution of prematurity to more-severe outcomes.
Even today, the prevention of prematurity is a major challenge not only because of its multifactorial nature but also because the various causes are not subject to prevention. Thus, when premature delivery is inevitable, the use of antenatal corticosteroids is the only effective intervention for reducing neonatal complications such as RDS, intracranial hemorrhage, necrotizing enterocolitis, and death. However, many misconceptions arise in this area, and hasty conclusions and contradictory information are frequent. These often arise from studies that do not allow to draw the conclusions that are proclaimed.
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