Hormonal and serum marker evaluation in patients with abortion - Revista Brasileira de Ginecologia e Obstetrícia

Hormonal and serum marker evaluation in patients with abortion |

Predicting pregnancy outcome from one or more maternal serum factors has been the subject of numerous investigations with controversial results. The aim of this study was to evaluate the serum levels of CA-125, CA-19.9, CA-15.3, beta-hCG, estradiol, progesterone, alpha-fetoprotein and CEA in women with abortion (n=18) and with pregnancy complicated by bleeding (n=6), in comparison to the serum levels of the control group (n=7). The results showed that the serum levels of CA-125 were significantly increased in the abortion group (153.9 ± 43.3 IU/ml), but no difference was detected in pregnancy complicated by bleeding (17.4 ± 2.6 IU/ml), as compared to control (24.7 ± 13.4 IU/ml). However, high serum levels of CA-19.9 were found in the group with pregnancy complicated by bleeding in comparison with the abortion group (20.2 ± 11.4 IU/ml versus 6.6 ± 1.4 IU/ml, respectively). In relation to hormone serum levels, both, the abortion (17.38 ± 9.4 ng/ml) and bleeding (18.3 ± 8.9 ng/ml) groups showed lower serum levels of progesterone, as compared to control (60.4 ± 26.8 ng/ml). Besides, women with abortion had additional low estradiol serum levels, when compared to controls (1,327 ± 1,015 ng/ml versus 10,774 ± 9,244 ng/ml). It was concluded that the serum levels of progesterone, CA-19.9 and beta-hCG seem to add valuable information to the evaluation of a pregnancy complicated by bleeding.