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Summary
Revista Brasileira de Ginecologia e Obstetrícia. 2010;32(2):100-100
Summary
Revista Brasileira de Ginecologia e Obstetrícia. 2010;32(2):100-100
Summary
Revista Brasileira de Ginecologia e Obstetrícia. 2006;28(2):101-106
DOI 10.1590/S0100-72032006000200005
PURPOSE: to evaluate the effects of conjugated equine estrogens (CEE) and raloxifene (Ral), alone or combined, on the rat endometrium. METHODS: fifty-six adult rats were ovariectomized and randomly divided into seven groups: GCont (control); GCEE (CEE 50 µg/kg); GCEE/25 (CEE 25 µg/kg); GRal/0.75 (Ral 0.75 mg/kg); GRal/0.4 (Ral 0.4 mg/kg); GCEERal (50/0.75) - (CEE 50 µg/kg + Ral 0.75 mg/kg), and GCEE-Ral (25/0.4) - (CEE 25 µg/kg + Ral 0.4 mg/kg). The drugs were orally administered (gavage) for 21 consecutive days. At the end of the experiment, all animals were anesthetized and sacrificed. Fragments of uterus were removed, fixed in 10% formaldehyde and processed for paraffin inclusion. The histological sections were stained by HE and submitted to histomorphometric evaluation. The following parameters were analyzed: thickness of superficial epithelium and number of endometrial glands/mm² and of blood vessels/mm². The data were evaluated using ANOVA followed by the Turkey-Kramer test. RESULTS: in the GCont and only Ral treatment (GRal/0.75 and GRal/0.4) the endometrium showed signals of atrophy. In the groups treated with only CEE signs of endometrial proliferation were observed, mainly in group GCEE/50. Also, there was endometrial proliferation in the groups that received combined CEE and Ral (Ral GCEE (50/0.75) and GCEE-Ral (25/0.4)), but it was more intensive in the animals treated with isolated estrogen than in those that received combined estrogen and raloxifene. CONCLUSION: raloxifene may partially block the action of estrogen on the castrated adult rat endometrium.
Summary
Revista Brasileira de Ginecologia e Obstetrícia. 2006;28(2):101-106
DOI 10.1590/S0100-72032006000200005
PURPOSE: to evaluate the effects of conjugated equine estrogens (CEE) and raloxifene (Ral), alone or combined, on the rat endometrium. METHODS: fifty-six adult rats were ovariectomized and randomly divided into seven groups: GCont (control); GCEE (CEE 50 µg/kg); GCEE/25 (CEE 25 µg/kg); GRal/0.75 (Ral 0.75 mg/kg); GRal/0.4 (Ral 0.4 mg/kg); GCEERal (50/0.75) - (CEE 50 µg/kg + Ral 0.75 mg/kg), and GCEE-Ral (25/0.4) - (CEE 25 µg/kg + Ral 0.4 mg/kg). The drugs were orally administered (gavage) for 21 consecutive days. At the end of the experiment, all animals were anesthetized and sacrificed. Fragments of uterus were removed, fixed in 10% formaldehyde and processed for paraffin inclusion. The histological sections were stained by HE and submitted to histomorphometric evaluation. The following parameters were analyzed: thickness of superficial epithelium and number of endometrial glands/mm² and of blood vessels/mm². The data were evaluated using ANOVA followed by the Turkey-Kramer test. RESULTS: in the GCont and only Ral treatment (GRal/0.75 and GRal/0.4) the endometrium showed signals of atrophy. In the groups treated with only CEE signs of endometrial proliferation were observed, mainly in group GCEE/50. Also, there was endometrial proliferation in the groups that received combined CEE and Ral (Ral GCEE (50/0.75) and GCEE-Ral (25/0.4)), but it was more intensive in the animals treated with isolated estrogen than in those that received combined estrogen and raloxifene. CONCLUSION: raloxifene may partially block the action of estrogen on the castrated adult rat endometrium.
Summary
Revista Brasileira de Ginecologia e Obstetrícia. 2008;30(2):101-101
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Revista Brasileira de Ginecologia e Obstetrícia. 2008;30(2):101-101
Summary
Revista Brasileira de Ginecologia e Obstetrícia. 2008;30(2):101-101
Summary
Revista Brasileira de Ginecologia e Obstetrícia. 2008;30(2):101-101
Summary
Revista Brasileira de Ginecologia e Obstetrícia. 2000;22(2):101-106
DOI 10.1590/S0100-72032000000200007
Purpose: to evaluate the prevalence of anticardiolipin antibody in women with stillbirth. Patients and Methods: this was a cross-sectional study performed from May 1998 to September 1999 at the Maternity of the University of Campinas and at the Hospital and Maternity Leonor Mendes de Barros, in Brazil, which evaluated 109 pregnant women hospitalized with the diagnosis of intrauterine fetal death and gestational age of 20 or more weeks. These women underwent some laboratory examinations to identify the cause of fetal death, including anticardiolipin antibody evaluation performed through the determination of IgG and IgM serum levels. IgG and IgM results are expressed as GPL and MPL units, respectively, and, in both cases, results above 10 units are considered positive. The statistical procedures used were the mean and standard deviation estimates, Student's t test, Fisher test and chi². Results: the prevalence of anticardiolipin positivity was 18.3%. The women were predominantly young, with a mean age around 27 years. The main identified causes of fetal death were: hypertension (26.1%), hemorrhage during the third trimester (9.9%) and fetal malformation (8.1%). One third of the cases had no identified causes of fetal death. However, considering the 20 positive cases for anticardiolipin antibody, the proportion of unidentified causes decreased to 29%. Conclusions: it is important to investigate the presence of anticardiolipin antibodies among women with intrauterine fetal death with the purpose of clarifying the causes of stillbirth. If the diagnosis of antiphospholipid syndrome is confirmed, it is necessary to counsel and treat these women regarding future pregnancies.
Summary
Revista Brasileira de Ginecologia e Obstetrícia. 2000;22(2):101-106
DOI 10.1590/S0100-72032000000200007
Purpose: to evaluate the prevalence of anticardiolipin antibody in women with stillbirth. Patients and Methods: this was a cross-sectional study performed from May 1998 to September 1999 at the Maternity of the University of Campinas and at the Hospital and Maternity Leonor Mendes de Barros, in Brazil, which evaluated 109 pregnant women hospitalized with the diagnosis of intrauterine fetal death and gestational age of 20 or more weeks. These women underwent some laboratory examinations to identify the cause of fetal death, including anticardiolipin antibody evaluation performed through the determination of IgG and IgM serum levels. IgG and IgM results are expressed as GPL and MPL units, respectively, and, in both cases, results above 10 units are considered positive. The statistical procedures used were the mean and standard deviation estimates, Student's t test, Fisher test and chi². Results: the prevalence of anticardiolipin positivity was 18.3%. The women were predominantly young, with a mean age around 27 years. The main identified causes of fetal death were: hypertension (26.1%), hemorrhage during the third trimester (9.9%) and fetal malformation (8.1%). One third of the cases had no identified causes of fetal death. However, considering the 20 positive cases for anticardiolipin antibody, the proportion of unidentified causes decreased to 29%. Conclusions: it is important to investigate the presence of anticardiolipin antibodies among women with intrauterine fetal death with the purpose of clarifying the causes of stillbirth. If the diagnosis of antiphospholipid syndrome is confirmed, it is necessary to counsel and treat these women regarding future pregnancies.
Summary
Revista Brasileira de Ginecologia e Obstetrícia. 2002;24(2):101-106
DOI 10.1590/S0100-72032002000200005
Purpose: to analyze the prevalence of gonorrhea, Chlamydia, syphilis and HIV among patients attending a family planning clinic regarding presence of STD symptoms and risk behaviors. Methods: women between the ages of 18 and 30 years who attended a public family planning clinic in Brazil were tested for gonorrhea and Chlamydia using the urine-based DNA amplification test (LCR, Abbott), and a blood test for syphilis (VDRL) and HIV. All participants were asked questions about their health care seeking behavior, the presence of STD symptoms, and about the STD risk behaviors. Results: Chlamydia was found in 11.4%, syphilis in 2%, gonorrhea in 0.5% and HIV was confirmed positive in 3%. Approximately 61% of the women who were infected with Chlamydia had no symptoms. Women who never used condoms had much higher risks for STD than women who used them always or most of the time. Although not statistically significant, there was a trend for women who never used any contraceptive to have a higher risk for STD than women who used some method of contraception (p=0.09). However, when examining separately each contraceptive, none of them alone offered protection against STD. Very few women reported problems related to the use of alcohol or illegal drugs. But among those who did report such use, the risk for STD was very high, particularly regarding marijuana use. Conclusions: the most significant findings in our study were the high STD rates among a population of women generally reporting low-risk health behaviors. Based upon our findings it is crucial to offer STD/HIV screening to all women under 30 years who visit public family planning clinics. Without screening all women, more than half of the infected women will never be identified or treated. Given the new sensitive and specific technology available to screen for Chlamydia, gonorrhea, and HIV, and the ease of collecting urine specimens for diagnosis, more efforts should be directed to surveillance of populations at risk, so that current clinical practice may reflect the true risk of the populations.
Summary
Revista Brasileira de Ginecologia e Obstetrícia. 2002;24(2):101-106
DOI 10.1590/S0100-72032002000200005
Purpose: to analyze the prevalence of gonorrhea, Chlamydia, syphilis and HIV among patients attending a family planning clinic regarding presence of STD symptoms and risk behaviors. Methods: women between the ages of 18 and 30 years who attended a public family planning clinic in Brazil were tested for gonorrhea and Chlamydia using the urine-based DNA amplification test (LCR, Abbott), and a blood test for syphilis (VDRL) and HIV. All participants were asked questions about their health care seeking behavior, the presence of STD symptoms, and about the STD risk behaviors. Results: Chlamydia was found in 11.4%, syphilis in 2%, gonorrhea in 0.5% and HIV was confirmed positive in 3%. Approximately 61% of the women who were infected with Chlamydia had no symptoms. Women who never used condoms had much higher risks for STD than women who used them always or most of the time. Although not statistically significant, there was a trend for women who never used any contraceptive to have a higher risk for STD than women who used some method of contraception (p=0.09). However, when examining separately each contraceptive, none of them alone offered protection against STD. Very few women reported problems related to the use of alcohol or illegal drugs. But among those who did report such use, the risk for STD was very high, particularly regarding marijuana use. Conclusions: the most significant findings in our study were the high STD rates among a population of women generally reporting low-risk health behaviors. Based upon our findings it is crucial to offer STD/HIV screening to all women under 30 years who visit public family planning clinics. Without screening all women, more than half of the infected women will never be identified or treated. Given the new sensitive and specific technology available to screen for Chlamydia, gonorrhea, and HIV, and the ease of collecting urine specimens for diagnosis, more efforts should be directed to surveillance of populations at risk, so that current clinical practice may reflect the true risk of the populations.
Summary
Revista Brasileira de Ginecologia e Obstetrícia. 2001;23(2):101-105
DOI 10.1590/S0100-72032001000200007
Purpose: to study the changes in amniotic fluid index (AFI) measured by ultrasonography, mean arterial pressure (MAP) and pulse rate in normal pregnant women submitted to subtotal body immersion in water for different periods of time, and to standardize the technique. Methods: AFI values were studied as recommended by Phelan et al.¹ in a group of 52 pregnant women with gestational age of 28 weeks or more considered to be clinically normal, before and after exposure to subtotal immersion in water heated to 32 to 34ºC for 30, 45 and 60 min. The patients were seen at the Ultrasonography and Medical Updating School of Ribeirão Preto and in the Department of Gynecology and Obstetrics of the Faculty of Medicine of Ribeirão Preto, University of São Paulo. Results: before and after immersion, the average of MAP was 87.8 and 87.1 in the group of 30 min, 76.7 and 66.6 in the group of 45 min and 77.4 and 60.7 in the group of 60 min, with statistical significance. Before and after immersion, the means of pulse rates were 74.9 and 78.7 in the group of 30 min, 83.6 and 85.2 in the group of 45 min and 84.9 and 90.6 in the group of 60 min, with statistical significance. The mean of AFI also showed statistical significance. When submitted to 30-min immersion the means of AFI were 11.7 cm before and 16.8 cm after. In the group of 45 min, the averages were 9.7 cm before and 13.8 cm after immersion. In the group of 60 min, the averages were 9.5 cm before and 13.6 cm after immersion. The time of immersion of 30-min was as effective and ample as 45 or 60 min. Conclusions: subtotal immersion in water is a safe and practical procedure that can mobilize fluids during pregnancy, increasing amniotic fluid volume.
Summary
Revista Brasileira de Ginecologia e Obstetrícia. 2001;23(2):101-105
DOI 10.1590/S0100-72032001000200007
Purpose: to study the changes in amniotic fluid index (AFI) measured by ultrasonography, mean arterial pressure (MAP) and pulse rate in normal pregnant women submitted to subtotal body immersion in water for different periods of time, and to standardize the technique. Methods: AFI values were studied as recommended by Phelan et al.¹ in a group of 52 pregnant women with gestational age of 28 weeks or more considered to be clinically normal, before and after exposure to subtotal immersion in water heated to 32 to 34ºC for 30, 45 and 60 min. The patients were seen at the Ultrasonography and Medical Updating School of Ribeirão Preto and in the Department of Gynecology and Obstetrics of the Faculty of Medicine of Ribeirão Preto, University of São Paulo. Results: before and after immersion, the average of MAP was 87.8 and 87.1 in the group of 30 min, 76.7 and 66.6 in the group of 45 min and 77.4 and 60.7 in the group of 60 min, with statistical significance. Before and after immersion, the means of pulse rates were 74.9 and 78.7 in the group of 30 min, 83.6 and 85.2 in the group of 45 min and 84.9 and 90.6 in the group of 60 min, with statistical significance. The mean of AFI also showed statistical significance. When submitted to 30-min immersion the means of AFI were 11.7 cm before and 16.8 cm after. In the group of 45 min, the averages were 9.7 cm before and 13.8 cm after immersion. In the group of 60 min, the averages were 9.5 cm before and 13.6 cm after immersion. The time of immersion of 30-min was as effective and ample as 45 or 60 min. Conclusions: subtotal immersion in water is a safe and practical procedure that can mobilize fluids during pregnancy, increasing amniotic fluid volume.
Summary
Revista Brasileira de Ginecologia e Obstetrícia. 2015;37(3):101-104
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Revista Brasileira de Ginecologia e Obstetrícia. 2015;37(3):101-104